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With the anti-obesity pharmacotherapy landscape rapidly evolving, two investigational agents from Eli Lilly have recently demonstrated highly promising Phase 2 results: Retatrutide (LY3437943) and Eloralintide (LY3841136)

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Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are gaining increasing attention as first-line agents for the treatment of diabetes and obesity, and with their potential to improve the muscle mass and function, they provide new ideas for the treatment of sarcopenia

PubMed, Scopus, and Web of Science were searched comprehensively on February 26, 2024, to locate randomized controlled trials (RCTs) assessing semaglutide's impact on cardiovascular outcomes