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If orforglipron receives approval for obesity in April 2026, it will enter a market that Morgan Stanley estimates could reach $100 billion annually by the early 2030s, potentially transforming Eli Lilly's already dominant position in the metabolic disease space

[DOI] [PubMed] [Google Scholar] 66.Mondragon A, Davidsson D, Kyriakoudi S, Bertling A, Gomes-Faria R, Cohen P, Rothery S, Chabosseau P, Rutter GA, da Silva Xavier G

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28 , 29 Subgroup analyses from various cardiovascular outcomes trials have also shown that GLP-1 RAs may benefit kidney-related outcomes, including reductions in albuminuria, slower declines in estimated glomerular filtration rate, and a decreased risk of end-stage kidney disease in patients with and without diabetes