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Standing up too quickly or changes in posture can then trigger orthostatic hypotension, a condition where dizziness follows sudden position changes

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These cells have a myriad of functions including sensing of the various nutrients we ingest (carbs, fats, amino acids) along with detection of pathogens and inflammatory signals

continued treatment helps maintain losses Common side effects that may affect treatment adherence include: Nausea and vomiting (usually temporary, improving after several weeks) Diarrhoea or constipation Abdominal discomfort Fatigue Injection site reactions Important safety considerations include: Risk of hypoglycaemia if used with insulin or sulfonylureas [4] Do not stop or reduce insulin rapidly without medical advice (risk of diabetic ketoacidosis) [4] Maintain adequate hydration to prevent acute kidney injury [4] Potential for gallbladder problems (pain, stones) Rare risk of intestinal obstruction Possible worsening of diabetic retinopathy in people with diabetes during rapid improvement in blood glucose For tirzepatide: use additional non-oral contraception for 4 weeks after initiation and each dose escalation Patients should contact their GP if they experience: persistent vomiting preventing fluid intake, severe abdominal pain, signs of gallbladder disease, or unusual thyroid symptoms