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Each assay was focused on a single substrate using the optimized concentration of relevant inhibitor: etomoxir (ETO) (4 m) to inhibit oxidation of long chain fatty acid (LCFAs), UK5099 (2 m) to inhibit the oxidation of glucose and/or pyruvate, and BPTES (3 m) to inhibit oxidation of glutamine

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Since macrophages are key immune cells in the fight against cancer and pathogen invasion ( Molecular and Cellular Mechanisms of Tamoxifen Action On and Off-Targets Orally administered tamoxifen undergoes hepatic conversion into active metabolites, such as 4-hydroxytamoxifen (4HT), that compete with the endogenous sex steroid hormones, estrogens, for binding to intracellular receptors, estrogen receptor alpha (ER ) and beta (ER )

The Wegovy titration schedule is designed to minimise side effects, but individual tolerance varies