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A recent study also found that exercise-induced neurogenesis that occurs in the adult hippocampus is mediated by SELENOP (Leiter et al., 2022)
2013;5:a017459
46,47 These effects are mediated by SIRT1 pathway activation, which optimizes mitochondrial function and autophagy, and by miRNA-dependent regulation (e.g., miR-146a targeting Nrf2/NF-B pathways), although the mechanisms vary across cell types and microenvironments
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