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Similarly, growth hormone (GH) may be related to ALS as one trial found that ALS patients had impaired GH secretion compared to healthy controls (Morselli 2006)

ROS is a known inducer of cell proliferation (73)

AP1 is a complex of several proteins including JUN, which is upregulated in motor neurons derived from SOD1 patients compared to other neurons, providing potential mechanistic insights into the selective degeneration of motor neurons in ALS (Bhinge et al., 2005)

MDSUPDRS motor scores and data on dopaminergic treatment were not available for the subjects covered for the transcriptomics profiling, and therefore the comparison of metabolomics and transcriptomics data focused on the case-control analyses and shared network alterations, confirming the treatment-independence using the metabolomics data (see section on Pathway and network analyses below)