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It is important to note that the positive health impact of the MeD derives from the synergy of bioactive compounds and nutrients that interact with each other, producing increasing beneficial effects, which cannot be replicated by pharmacologically supplementing a single component [15, 62, 175, 190]

All procedures were carried out under Institutional Animal Care and Use Committee approval and in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals

In adults, these defects are usually characterized by the accumulation of medium-chain and long-chain (3-hydroxy) carnitine derivatives, and they are associated with lipotoxicity in several organs that can lead to life-threatening complications and comorbidities

Therapeutic hypothermia achieves neuroprotection via a decrease in acetylcholine with a concurrent increase in carnitine in the neonatal hypoxia-ischemia